Department of Cell Biology

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Artur Mayerhofer

The Molecular Signature of Human Testicular Peritubular Cells Revealed by Single-Cell Analysis.
Liebich A, Schmid N, Koupourtidou C, Herrmann C, Dietrich KG, Welter H, Ninkovic J, Mayerhofer A.  Cells. 2022 Nov 19;11(22):3685. doi: 10.3390/cells11223685. PMID: 36429113; PMCID: PMC9688777.

Profound Effects of Dexamethasone on the Immunological State, Synthesis and Secretion Capacity of Human Testicular Peritubular Cells.
Stepanov YK, Speidel JD, Herrmann C, Schmid N, Behr R, Köhn FM, Stöckl JB, Pickl U, Trottmann M, Fröhlich T, Mayerhofer A, Welter H. Cells. 2022 Oct 9;11(19):3164. doi: 10.3390/cells11193164. PMID: 36231125; PMCID: PMC9562650.

Evidence of a role for cAMP in mitochondrial regulation in ovarian granulosa cells.
Kaseder M, Schmid N, Eubler K, Goetz K, Müller-Taubenberger A, Dissen GA, Harner M, Wanner G, Imhof A, Forne I, Mayerhofer A.  Mol Hum Reprod. 2022 Aug 9:gaac030. doi: 10.1093/molehr/gaac030. Epub ahead of print. PMID: 35944223.

Single-cell analysis of human testis aging and correlation with elevated body mass index.
Nie X, Munyoki SK, Sukhwani M, Schmid N, Missel A, Emery BR, DonorConnect, Stukenborg JB, Mayerhofer A, Orwig KE, Aston KI, Hotaling JM, Cairns BR, Guo J. Dev Cell. 2022 May 9;57(9):1160-1176.e5. doi: 10.1016/j.devcel.2022.04.004. Epub 2022 May 2. PMID: 35504286; PMCID: PMC9090997.

Pleiotropic actions of melatonin in testicular peritubular myoid cells of immature Syrian hamsters.
Riviere E, Rossi SP, Tavalieri YE, Muñoz de Toro MM, Calandra RS, Mayerhofer A, Matzkin ME, Frungieri MB.  Biochim Biophys Acta Gen Subj. 2022 Jun 9:130187. doi: 10.1016/j.bbagen.2022.130187. Epub ahead of print. PMID: 35691458.

The role of resveratrol, Sirtuin1 and RXRα as prognostic markers in ovarian cancer.
Chen F, Kolben T, Meister S, Czogalla B, Kolben TM, Hester A, Burges A, Trillsch F, Schmoeckel E, Mayr D, Mayerhofer A, Mahner S, Jeschke U, Beyer S. Arch Gynecol Obstet. 2022 Jun;305(6):1559-1572. doi: 10.1007/s00404-021-06262-w. Epub 2021 Dec 6. PMID: 34870752; PMCID: PMC9166836.

A rapid and robust method for the cryopreservation of human granulosa cells.
Beschta S, Eubler K, Bohne N, Forne I, Berg D, Berg U, Mayerhofer A.
Histochem Cell Biol. 2021 Jul 27. doi: 10.1007/s00418-021-02019-3. Epub ahead of print. PMID: 34313845.

Age-Related Alterations in the Testicular Proteome of a Non-Human Primate.
Stöckl JB, Schmid N, Flenkenthaler F, Drummer C, Behr R, Mayerhofer A, Arnold GJ, Fröhlich T.
Cells. 2021 May 24;10(6):1306. doi: 10.3390/cells10061306. PMID: 34074003; PMCID: PMC8225046.

Testicular adenosine acts as a pro-inflammatory molecule: role of testicular peritubular cells.
Missel A, Walenta L, Eubler K, Mundt N, Heikelä H, Pickl U, Trottmann M, Popper B, Poutanen M, Strauss L, Köhn FM, Kunz L, Spehr M, Mayerhofer A.
Mol Hum Reprod. 2021 Jul 1;27(7):gaab037. doi: 10.1093/molehr/gaab037. PMID: 33993290.

Exploring the Ion Channel TRPV2 and Testicular Macrophages in Mouse Testis.
Eubler K, Rantakari P, Gerke H, Herrmann C, Missel A, Schmid N, Walenta L, Lahiri S, Imhof A, Strauss L, Poutanen M, Mayerhofer A.
Int J Mol Sci. 2021 Apr 29;22(9):4727. doi: 10.3390/ijms22094727. PMID: 33946947; PMCID: PMC8124949.

Sirtuin 1 and Sirtuin 3 in Granulosa Cell Tumors.
Schmid N, Dietrich KG, Forne I, Burges A, Szymanska M, Meidan R, Mayr D, Mayerhofer A.
Int J Mol Sci. 2021 Feb 19;22(4):2047. doi: 10.3390/ijms22042047. PMID: 33669567; PMCID: PMC7923107.

ATP activation of peritubular cells drives testicular sperm transport.
Fleck D, Kenzler L, Mundt N, Strauch M, Uesaka N, Moosmann R, Bruentgens F, Missel A, Mayerhofer A, Merhof D, Spehr J, Spehr M.
Elife. 2021 Jan 27;10:e62885. doi: 10.7554/eLife.62885. PMID: 33502316; PMCID: PMC7840184.

MALDI-IMS combined with shotgun proteomics identify and localize new factors in male infertility.
Lahiri S, Aftab W, Walenta L, Strauss L, Poutanen M, Mayerhofer A, Imhof A.
Life Sci Alliance. 2021 Jan 6;4(3):e202000672. doi: 10.26508/lsa.202000672. Erratum in: Life Sci Alliance. 2021 Jan 21;4(3): PMID: 33408244; PMCID: PMC7812314.

Correction: MALDI-IMS combined with shotgun proteomics identify and localize new factors in male infertility.
Lahiri S, Aftab W, Walenta L, Strauss L, Poutanen M, Mayerhofer A, Imhof A.
Life Sci Alliance. 2021 Jan 21;4(3):e202101015. doi: 10.26508/lsa.202101015. Erratum for: Life Sci Alliance. 2021 Jan 6;4(3): PMID: 33479050; PMCID: PMC7918713.

Filamin A Orchestrates Cytoskeletal Structure, Cell Migration and Stem Cell Characteristics in Human Seminoma TCam-2 Cells.
Welter H, Herrmann C, Fröhlich T, Flenkenthaler F, Eubler K, Schorle H, Nettersheim D, Mayerhofer A, Müller-Taubenberger A.
Cells. 2020 Nov 30;9(12):2563. doi: 10.3390/cells9122563. PMID: 33266100; PMCID: PMC7761120.

Huperzine-A administration recovers rat ovary function after sympathetic stress.
Riquelme R, Ruz F, Mayerhofer A, Lara HE.
J Neuroendocrinol. 2021 Jan;33(1):e12914. doi: 10.1111/jne.12914. Epub 2020 Nov 30. PMID: 33252842.

Proteomic Insights into Senescence of Testicular Peritubular Cells from a Nonhuman Primate Model.
Stöckl JB, Schmid N, Flenkenthaler F, Drummer C, Behr R, Mayerhofer A, Arnold GJ, Fröhlich T.
Cells. 2020 Nov 17;9(11):2498. doi: 10.3390/cells9112498. PMID: 33213088; PMCID: PMC7698562.

Palmitic Acid Targets Human Testicular Peritubular Cells and Causes a Pro-Inflammatory Response.
Mayerhofer A, Dietrich KG, Urbanski HF, Köhn FM, Pickl U, Trottmann M, Kievit P, Welter H.J
Clin Med. 2020 Aug 17;9(8):2655. doi: 10.3390/jcm9082655. PMID: 32824411; PMCID: PMC7463762.

A translational cellular model for the study of peritubular cells of the testis.
Schmid N, Missel A, Petkov S, Stöckl JB, Flenkenthaler F, Arnold GJ, Fröhlich T, Behr R, Mayerhofer A. 
Reproduction. 2020 Aug;160(2):259-268. doi: 10.1530/REP-20-0100. PMID: 32449695.

Sirtuin1 expression and survival in endometrial and clear-cell uterine cancer.
Beyer S, Chen F, Meister S, Czogalla B, Kolben TM, Hester A, Burges A, Trillsch F, Schmöckel E, Mayr D, Mayerhofer A, Mahner S, Jeschke U, Kolben T.
Histochem Cell Biol. 2020 Aug;154(2):189-195. doi: 10.1007/s00418-020-01873-x. Epub 2020 May 9. PMID: 32388637; PMCID: PMC7429549.

The Glucocorticoid Receptor NR3C1 in Testicular Peritubular Cells is Developmentally Regulated and Linked to the Smooth Muscle-Like Cellular Phenotype.
Welter H, Herrmann C, Dellweg N, Missel A, Thanisch C, Urbanski HF, Köhn FM, Schwarzer JU, Müller-Taubenberger A, Mayerhofer A.
J Clin Med. 2020 Mar 31;9(4):961. doi: 10.3390/jcm9040961. PMID: 32244354; PMCID: PMC7230580.

A Role for H(2)O(2) and TRPM2 in the Induction of Cell Death: Studies in KGN Cells.
Hack CT, Buck T, Bagnjuk K, Eubler K, Kunz L, Mayr D, Mayerhofer A.  
Antioxidants (Basel). 2019 Oct 29;8(11). pii: E518. doi: 10.3390/antiox8110518.PubMed PMID: 31671815.

Insights into replicative senescence of human testicular peritubular cells.
Schmid N, Flenkenthaler F, Stöckl JB, Dietrich KG, Köhn FM, Schwarzer JU, KunzL, Luckner M, Wanner G, Arnold GJ, Fröhlich T, Mayerhofer A.  
Sci Rep. 2019 Oct 21;9(1):15052. doi: 10.1038/s41598-019-51380-w. PubMed PMID: 31636313; PubMedCentral PMCID: PMC6803627

Inhibitor of apoptosis proteins are potential targets for treatment of granulosa cell tumors - implications from studies in KGN.
Bagnjuk K, Kast VJ, Tiefenbacher A, Kaseder M, Yanase T, Burges A, Kunz L, Mayr D, Mayerhofer A.  
J Ovarian Res. 2019 Aug 14;12(1):76. doi: 10.1186/s13048-019-0549-6. PubMed PMID: 31412918; PubMed Central PMCID: PMC6694575.

β-adrenergic receptors in the up-regulation of COX2 expression and prostaglandin production in testicular
macrophages: Possible relevance to male idiopathic infertility.
Matzkin ME, Riviere E, Rossi SP, Ponzio R, Puigdomenech E, Levalle O, Terradas C, Calandra RS, Mayerhofer A, Frungieri MB.  Mol Cell
Endocrinol. 2019 Dec 1;498:110545. doi: 10.1016/j.mce.2019.110545. Epub 2019 Aug
16. PubMed PMID: 31425733.

Human Luteinized Granulosa Cells-A Cellular Model for the Human Corpus Luteum.
Bagnjuk K, Mayerhofer A.
Front Endocrinol (Lausanne). 2019 Jul 9;10:452. doi:10.3389/fendo.2019.00452. eCollection 2019. Review.

Aging in the Syrian hamster testis: Inflammatory-oxidative status and the impact of photoperiod.
Matzkin ME, Valchi P, Riviere E, Rossi SP, Tavalieri YE, Muñoz de Toro MM, Mayerhofer A, Bartke A, Calandra RS, Frungieri MB.  Exp
Gerontol. 2019 Sep;124:110649. doi: 10.1016/j.exger.2019.110649. Epub 2019 Jul 2.
PubMed PMID: 31276778.

Peritubular cells of the human testis: prostaglandin E(2) and more.
Mayerhofer A.
Andrology. 2019 Jun 24. doi: 10.1111/andr.12669. [Epub ahead of print] Review.

Role of ovarian sympathetic nerves and cholinergic local system during cold stress.
Riquelme R, Ruz F, Mayerhofer A, Lara H.
J Endocrinol. 2019 Jun 1. pii:JOE-19-0125.R2. doi: 10.1530/JOE-19-0125. [Epub ahead of print]

Signal peptide peptidase-like 2c impairs vesicular transport and cleaves SNARE proteins.
Papadopoulou AA, Müller SA, Mentrup T, Shmueli MD, Niemeyer J, Haug-Kröper M, von Blume J, Mayerhofer A, Feederle R, Schröder B, Lichtenthaler SF, Fluhrer R.
EMBO Rep. 2019 May;20(5). pii: e48133. doi: 10.15252/embr.201948133.

The NADPH oxidase 4 is a major source of hydrogen peroxide in human granulosa-lutein and granulosa tumor cells.
Buck T, Hack CT, Berg D, Berg U, Kunz L, Mayerhofer A.
Sci Rep. 2019 Mar 5;9(1):3585.

Necroptosis in primate luteolysis: a role for ceramide.
Bagnjuk K, Stöckl JB, Fröhlich T, Arnold GJ, Behr R, Berg U, Berg D, Kunz L, Bishop C, Xu J, Mayerhofer A.  
Cell Death Discov. 2019 Feb 11;5:67.

Signal Peptide Peptidase-Like 2c (SPPL2c) impairs vesicular transport and cleavage of SNARE proteins.
Papadopoulou AA, Müller SA, Mentrup T, Shmueli MD, Niemeyer J, Haug-Kröper M, von Blume J, Mayerhofer A, Feederle R, Schröder B, Lichtenthaler SF, Fluhrer R.
EMBO Rep. 2019 Mar;20(3)

The intramembrane protease SPPL2c promotes male germ cell development by cleaving phospholamban.
Niemeyer J, Mentrup T, Heidasch R, Müller SA, Biswas U, Meyer R, Papadopoulou
AA, Dederer V, Haug-Kröper M, Adamski V, Lüllmann-Rauch R, Bergmann M, Mayerhofer
A, Saftig P, Wennemuth G, Jessberger R, Fluhrer R, Lichtenthaler SF, Lemberg MK, Schröder B.  
EMBO Rep. 2019 Mar;20(3)

Human testicular peritubular cells, mast cells and testicular inflammation.
Mayerhofer A, Walenta L, Mayer C, Eubler K, Welter H.
Andrologia. 2018 Dec;50(11)

Ca(2+) Signaling and IL-8 Secretion in Human Testicular Peritubular Cells Involve the Cation Channel TRPV2.
Eubler K, Herrmann C, Tiefenbacher A, Köhn FM, Schwarzer JU, Kunz L,
Mayerhofer A.  Int J Mol Sci. 2018 Sep 19;19(9).

NLRP3 in Somatic Non-Immune Cells of Rodent and Primate Testes.
Walenta L, Schmid N, Schwarzer JU, Köhn FM, Urbanski H, Behr R, Strauss L,Poutanen M, Mayerhofer A.  Reproduction. 2018 Sep;156(3):231-238

Insights into the role of androgen receptor in human testicular peritubular cells. 
Mayer C, Adam M, Walenta L, Schmid N, Heikelä H, Schubert K, Flenkenthaler F, Dietrich KG, Gruschka S, Arnold GJ, Fröhlich T, Schwarzer JU, Köhn FM, Strauss L, Welter H, Poutanen M, Mayerhofer A.  
Andrology 2018 Sep;6(5):756-765

Characterization of a nonhuman primate model for the study of testicular peritubular cells - comparison
with human testicular cells.
Schmid N, Stöckl JB, Flenkenthaler F, Dietrich KG, Schwarzer JU, Köhn FM,
Drummer C, Fröhlich T, Arnold GJ, Behr R, Mayerhofer A.  
Mol Hum Reprod. 2018 Aug 1;24(8):401-410

Acetylcholine and necroptosis are players in follicular development in primates.
Du Y, Bagnjuk K, Lawson MS, Xu J, Mayerhofer A.
Sci Rep. 2018 Apr 18:8(1):6166

Neuropeptide and steroid hormone mediators of neuroendocrine regulation.
Heck AL, Crestani CC, Fernández-Guasti A, Larco DO, Mayerhofer A, Roselli CE.
J Neuroendocrinol. 2018 Oct;30(10)

ATP-mediated Events in Peritubular Cells Contribute to Sterile Testicular Inflammation.
Walenta L, Fleck D, Fröhlich T, von Eysmondt H, Arnold GJ, Spehr J, Schwarzer JU, Köhn FM, Spehr M, Mayerhofer A.  Sci Rep. 2018 Jan 23;8(1):1431.

Hydroxysteroid (17β) dehydrogenase 1 expressed by Sertoli cells contributes to steroid synthesis
and is required for male fertility.
Hakkarainen J, Zhang FP, Jokela H, Mayerhofer A, Behr R, Cisneros-Montalvo S,Nurmio M, Toppari J, Ohlsson C, Kotaja N, Sipilä P, Poutanen M.  
FASEB J. 2018 Jun;32(6):3229-3241

Prostaglandin E2 (PGE2) is a testicular peritubular cell-derived factor involved in human testicular homeostasis.
Verónica Rey-Ares, Soledad Paola Rossi, Kim-Gwendolyn Dietrich, Frank-Michael Köhn, J. Ulrich Schwarzer, Harald Welter, Mónica Beatriz Frungieri, Artur Mayerhofer.
Mol Cell Endocrinol. 2018 Sep 15;473:217-224

Alpha 1 adrenergic receptor-mediated inflammatory responses in human testicular peritubular cells.
Soledad Paola Rossi, Lena Walenta, Verónica Rey-Ares, Frank-Michael Köhn, J. Ullrich Schwarzer, Harald Welter, Ricardo Saúl Calandra, Mónica Beatriz Frungieri, Artur Mayerhofer.
Mol Cell Endocrinol. 2018 Oct 15;474:1-9

Sterile inflammation as a factor in human male infertility: Involvement of Toll like receptor 2, biglycan and peritubular cells.
Mayer C, Adam M, Glashauser L, Dietrich K, Schwarzer JU, Köhn FM, Strauss L, Welter H, Poutanen M, Mayerhofer A.    
Sci Rep. 2016 Nov 16;6:37128.

L-DOPA in the human ovarian follicular fluid acts as an antioxidant factor on granulosa cells.
Blohberger J, Buck T, Berg D, Berg U, Kunz L, Mayerhofer A.
J Ovarian Res. 2016 Sep 29;9(1):62. PubMed PMID: 27686972; PubMed Central PMCID:

In vivo blockade of acetylcholinesterase increases intraovarian acetylcholine and enhances follicular development and fertility in the rat.
Urra J, Blohberger J, Tiszavari M, Mayerhofer A, Lara HE.  
Sci Rep. 2016 Jul 21;6:30129.

Reactive oxygen species (ROS) production triggered by prostaglandin D(2) (PGD(2)) regulates lactate dehydrogenase (LDH) expression/activity in TM4 Sertoli cells.
Rossi SP, Windschüttl S, Matzkin ME, Rey-Ares V, Terradas C, Ponzio R,Puigdomenech E, Levalle O, Calandra RS, Mayerhofer A, Frungieri MB.  
Mol Cell Endocrinol. 2016 Jun 18;434:154-165.

The Rapamycin-Sensitive Complex of Mammalian Target of Rapamycin Is Essential to
Maintain Male Fertility.

Schell C, Kretz O, Liang W, Kiefer B, Schneider S, Sellung D, Bork T, Leiber C, Rüegg MA, Mallidis C, Schlatt S, Mayerhofer A, Huber TB, Grahammer F
Am J Pathol. 2016 Feb;186(2) : 324-36

Human testicular peritubular cells secrete pigment epithelium-derived factor (PEDF), which may be responsible for the avascularity of the seminiferous tubules.
Windschüttl S, Kampfer C, Mayer C, Flenkenthaler F, Fröhlich T, Schwarzer JU, Köhn FM, Urbanski H, Arnold GJ, Mayerhofer A.
Sci Rep. 2015 Sep 3;5:12820.

Pro-nerve growth factor in the ovary and human granulosa cells.
Meinel S, Blohberger J, Berg D, Berg U, Dissen GA, Ojeda SR, Mayerhofer A.
Horm Mol Biol Clin Investig. 2015 Nov;24(2) : 91-9.

Expression of the beta-2 adrenergic receptor (ADRB-2) in human and monkey ovarian follicles:
a marker of growing follicles?

Merz C, Saller S, Kunz L, Xu J, Yeoman RR, Ting AY, Lawson MS, Stouffer RL, Hennebold JD, Pau F, Dissen GA, Ojeda SR, Zelinski MB, Mayerhofer A.
J Ovarian Res. 2015 Mar 7;8(1):8.

Readthrough acetylcholinesterase (AChE-R) and regulated necrosis: pharmacological targets for the regulation of ovarian functions?
Blohberger J, Kunz L, Einwang D, Berg U, Berg D, Ojeda SR, Dissen GA, Fröhlich T, Arnold GJ, Soreq H, Lara H, Mayerhofer A.
Cell Death Dis. 2015 Mar 12;6:e1685. doi: 10.1038/cddis.2015.51.

Cyclooxygenase and prostaglandins in somatic cell populations of the testis.
Frungieri MB, Calandra RS, Mayerhofer A, Matzkin ME.
Reproduction. 2015 Apr;149(4):R169-R180.

The G-Protein-Coupled Estrogen Receptor (GPER/GPR30) in Ovarian Granulosa Cell Tumors.
Heublein S, Mayr D, Friese K, Jarrin-Franco MC, Lenhard M, Mayerhofer A, Jeschke U.
Int J Mol Sci. 2014 Aug 27;15(9):15161-72.

Human testicular peritubular cells host putative stem Leydig cells with steroidogenic capacity.
Landreh L, Spinnler K, Schubert K, Häkkinen MR, Auriola S, Poutanen M, Söder O, Svechnikov K, Mayerhofer A.
J Clin Endocrinol Metab. 2014 Jul;99(7):E1227-35.

Expression of the oestrogen receptor GPER by testicular peritubular cells is linked to sexual maturation and male fertility.
Sandner F, Welter H, Schwarzer JU, Köhn FM, Urbanski HF, Mayerhofer A.
Andrology. 2014 Sep;2(5):695-701.

Are testicular mast cells involved in the regulation of germ cells in man?
Windschüttl S, Nettersheim D, Schlatt S, Huber A, Welter H, Schwarzer JU, Köhn FM, Schorle H, Mayerhofer A.
Andrology. 2014 Jul;2(4):615-22.

Maternal sympathetic stress impairs follicular development and puberty of the offspring.
Barra R, Cruz G, Mayerhofer A, Paredes A, Lara HE.
Reproduction. 2014 Aug;148(2):137-45.

Angiotensin II regulates testicular peritubular cell function via AT1 receptor: a specific situation in male infertility.
Welter H, Huber A, Lauf S, Einwang D, Mayer C, Schwarzer JU, Köhn FM, Mayerhofer A.
Mol Cell Endocrinol. 2014 Aug 5;393(1-2):171-8.

Melatonin in testes of infertile men: evidence for anti-proliferative and anti-oxidant effects on local macrophage and mast cell populations.
Rossi SP, Windschuettl S, Matzkin ME, Terradas C, Ponzio R, Puigdomenech E, Levalle O, Calandra RS, Mayerhofer A, Frungieri MB.
Andrology. 2014 May;2(3):436-49.Artur Mayerhofer 

Pigment-Epithelium Derived Factor (PEDF) and the human ovary: A role in the generation of ROS in granulosa cells.
Kampfer C, Saller S, Windschüttl S, Berg D, Berg U, Mayerhofer A.
Life Sci. 2014 Mar 3;97(2):129-36. doi: 10.1016/j.lfs.2013.12.007. Epub 2013 Dec 17.

Secretome analysis of testicular peritubular cells: a window into the human testicular microenvironment and the spermatogonial stem cell niche in man.
Flenkenthaler F, Windschüttl S, Fröhlich T, Schwarzer JU, Mayerhofer A, Arnold GJ.
J Proteome Res. 2014 Mar 7;13(3):1259-69.

Dopamine in human follicular fluid is associated with cellular uptake and metabolism-dependent generation of reactive oxygen species in granulosa cells: implications for physiology and pathology.
Saller S, Kunz L, Berg D, Berg U, Lara H, Urra J, Hecht S, Pavlik R, Thaler CJ, Mayerhofer A.
Hum Reprod. 2014 Mar;29(3):555-67. doi: 10.1093/humrep/det422. Epub 2013 Nov 27.

Human testicular peritubular cells: more than meets the eye.
Mayerhofer A.
Reproduction. 2013 Apr 29;145(5):R107-16.

Partial loss of contractile marker proteins in human testicular peritubular cells in infertility patients.
Welter H, Kampfer C, Lauf S, Feil R, Schwarzer JU, Köhn FM, *Mayerhofer A*.
Andrology. 2013 Mar;1(2):318-24.

The Ca(2+)-activated, large conductance K(+)-channel (BK(Ca)) is a player in the LH/hCG signaling cascade in testicular Leydig cells.
Matzkin ME, Lauf S, Spinnler K, Rossi SP, Köhn FM, Kunz L, Calandra RS, Frungieri MB, *Mayerhofer A*.
Mol Cell Endocrinol. 2013 Mar 10;367(1-2):41-9.

Decorin is a part of the ovarian extracellular matrix in primates and may act as a signaling molecule.
Adam M, Saller S, Ströbl S, Hennebold JD, Dissen GA, Ojeda SR, Stouffer RL, Berg D, Berg U, *Mayerhofer A*.
Hum Reprod. 2012 Nov;27(11):3249-58.

Evidence for an adaptation in ROS scavenging systems in human testicular peritubular cells from infertility patients.
Kampfer C, Spillner S, Spinnler K, Schwarzer JU, Terradas C, Ponzio R, Puigdomenech E, Levalle O, Köhn FM, Matzkin ME, Calandra RS, Frungieri MB, *Mayerhofer A*.
Int J Androl. 2012 Dec;35(6):793-801.

Peritubular myoid cells have a role in postnatal testicular growth.
Nurmio M, Kallio J, Adam M, Mayerhofer A, Toppari J, Jahnukainen K.
Spermatogenesis. 2012 Apr 1;2 (2):79-87.

Norepinephrine, active norepinephrine transporter, and norepinephrine-metabolism are involved in the generation of reactive oxygen species in human ovarian granulosa cells.
Saller S, Merz-Lange J, Raffael S, Hecht S, Pavlik R, Thaler C, Berg D, Berg U, Kunz L, Mayerhofer A.
Endocrinology. 2012 Mar;153(3):1472-83. Epub 2012 Jan 10.

High levels of the extracellular matrix proteoglycan decorin are associated with inhibition of testicular function.#mce_temp_url#
Adam M, Urbanski HF, Garyfallou VT, Welsch U, Köhn FM, Ullrich Schwarzer J, Strauss L, Poutanen M, Mayerhofer A.
Int J Androl. 2011 Nov 15, doi: 10.1111/j.1365-2605.2011.01225.x. [Epub ahead of print]

M.B.Frungieri, S.I.Gonzalez-Calvar, M.E.Matzkin, S.P.Rossi, A. Mayerhofer, R.S Calandra
Acta Bioquimica Clin Latinoam, 2011;45 (4) 615-619 (Review)

Mast cells in human testicular biopsies from patients with mixed atrophy: increased numbers, heterogeneity, and expression of cyclooxygenase 2 and prostaglandin D2 synthase.#mce_temp_url#
Welter H, Köhn FM, Mayerhofer A.
Fertil Steril. 2011 Aug;96(2):309-13.

Human tryptase cleaves pro-nerve growth factor (PRO NGF): hints of a local, mast cell-dependent regulation of NGF/PRONGF action.
Spinnler K, Fröhlich T, Arnold GJ, Kunz L, Mayerhofer A.
J Biol Chem.2011 Sept 9; 286(36): 31707-13

Mast cell tryptase stimulates production of decorin by human testicular peritubular cells: possible role of decorin in male infertility by interfering with growth factor signaling.
Adam M, Schwarzer JU, Köhn FM, Strauss L, Poutanen M, Mayerhofer A.
Hum Reprod. 2011 Oct; 26(10): 2613-25

Glial cell line-derived neurotrophic factor is constitutively produced by human testicular peritubular cells and may contribute to the spermatogonial stem cell niche in man.
Spinnler K, Köhn FM, Schwarzer U, Mayerhofer A.
Hum Reprod. 2010 Sep;25(9):2181-7.

Connexin expression by human granulosa cell tumors: Identification of connexin 32 as a tumor signature.
Lücke, C., Siebert S., Mayr D., Mayerhofer A.
Cancer Biomark, 2010Jan 1; 8(3): 137-44

Cyclooxygenase-2 in testes of infertile men: evidence for the induction of prostaglandin synthesis by interleukin-1beta.
Matzkin ME, Mayerhofer A, Rossi SP, Gonzalez B, Gonzalez CR, Gonzalez-Calvar SI, Terradas C, Ponzio R, Puigdomenech E, Levalle O, Calandra RS, Frungieri MB.
Fertil Steril 94, 1933-1936, 2010.

Oxytocin receptors in the primate ovary: molecular identity and link to apoptosis in human granulosa cells.
Saller S, Kunz L, Dissen GA, Stouffer R, Ojeda SR, Berg D, Berg U, Mayerhofer A.
Hum Reprod 2010 Apr., 25(4): 969-76.

Cyclooxygenase-2 (COX-2) in testes of infertile men: evidence for the induction of prostaglandin (PG) synthesis by interleukin-1beta (IL-1beta)
María Eugenia Matzkin, Artur Mayerhofer, Soledad Paola Rossi, Betina Gonzalez, Candela Rocío Gonzalez, Silvia Inés Gonzalez-Calvar, Claudio Terradas, Roberto Ponzio, Elisa Puigdomenech, Oscar Levalle, Ricardo Saúl Calandra, and Mónica Beatriz Frungieri.
Fertility and Sterility, 2010 Oct; 94 (5): 1933-6

15-Deoxy-delta 12-14-prostaglandin-J2 induces hypertrophy and loss of contractility in human testicular peritubular cells: implications for human male fertility.
Schell C, Albrecht M, Spillner S, Mayer C, Kunz L, Kohn FM, Schwarzer U, Mayerhofer A.
Endocrinology 2010 Mar.,151, 1257-68

Accelerated stem cell labeling with ferucarbotran and protamine.
Golovko DM, Henning T, Bauer JS, Settles M, Frenzel T, Mayerhofer A, Rummeny EJ, Daldrup-Link HE.
Eur Radiol 20, 640-648, 2010.

Excessive ovarian production of nerve growth factor facilitates development of cystic ovarian morphology in mice and is a feature of polycystic ovarian syndrome in humans.
Dissen GA, Garcia-Rudaz C, Paredes A, Mayer C, Mayerhofer A, Ojeda SR.
Endocrinology 150, 2906-2914, 2009.

Testosterone induction of prostaglandin-endoperoxide synthase 2 expression and prostaglandin F(2alpha) production in hamster Leydig cells.
Matzkin ME, Gonzalez-Calvar SI, Mayerhofer A, Calandra RS, Frungieri MB.
Reproduction 138, 163-175, 2009.

Increased exposure to estrogens disturbs maturation, steroidogenesis, and cholesterol homeostasis via estrogen receptor alpha in adult mouse Leydig cells.
Strauss L, Kallio J, Desai N, Pakarinen P, Miettinen T, Gylling H, Albrecht M, Makela S, Mayerhofer A, Poutanen M.
Endocrinology 150, 2865-2872, 2009.

Identification and characterization of Ca2+-activated K+ channels in granulosa cells of the human ovary.
Traut MH, Berg D, Berg U, Mayerhofer A, Kunz L.
Reprod Biol Endocrinol 7, 28, 2009.

Catecholamine uptake, storage, and regulated release by ovarian granulosa cells.
Greiner M, Paredes A, Rey-Ares V, Saller S, Mayerhofer A, Lara HE.
Endocrinology 149, 4988-4996, 2008.

Exploring human testicular peritubular cells: identification of secretory products and regulation by tumor necrosis factor-alpha.
Schell C, Albrecht M, Mayer C, Schwarzer JU, Frungieri MB, Mayerhofer A.
Endocrinology 149, 1678-1686, 2008.

Ionizing radiation induces degranulation of human mast cells and release of tryptase.
Albrecht M, Muller K, Kohn FM, Meineke V, Mayerhofer A.
Int J Radiat Biol 83, 535-541, 2007.

Ovarian acetylcholine and ovarian KCNQ channels: insights into cellular regulatory systems of steroidogenic granulosa cells.
Kunz L, Roggors C, Mayerhofer A.
Life Sci 80, 2195-2198, 2007.

Dopamine receptor repertoire of human granulosa cells.
Rey-Ares V, Lazarov N, Berg D, Berg U, Kunz L, Mayerhofer A.
Reprod Biol Endocrinol 5, 40, 2007.

A prostaglandin D2 system in the human testis.
Schell C, Frungieri MB, Albrecht M, Gonzalez-Calvar SI, Kohn FM, Calandra RS, Mayerhofer A.
Fertil Steril 88, 233-236, 2007.

Protease activated receptor 2 and epidermal growth factor receptor are involved in the regulation of human sperm motility.
Zitta K, Albrecht M, Weidinger S, Mayerhofer A, Kohn F.
Asian J Androl 9, 690-696, 2007.

Isolation and cultivation of human testicular peritubular cells: a new model for the investigation of fibrotic processes in the human testis and male infertility.
Albrecht M, Ramsch R, Kohn FM, Schwarzer JU, Mayerhofer A.
J Clin Endocrinol Metab 91, 1956-1960, 2006.

Cyclooxygenase-2 and prostaglandin F2 alpha in Syrian hamster Leydig cells: Inhibitory role on luteinizing hormone/human chorionic gonadotropin-stimulated testosterone production.
Frungieri MB, Gonzalez-Calvar SI, Parborell F, Albrecht M, Mayerhofer A, Calandra RS.
Endocrinology 147, 4476-4485, 2006.

Voltage-dependent K+ channel acts as sex steroid sensor in endocrine cells of the human ovary.
Kunz L, Ramsch R, Krieger A, Young KA, Dissen GA, Stouffer RL, Ojeda SR, Mayerhofer A.
J Cell Physiol 206, 167-174, 2006.

The adenosine 5'-triphosphate-sensitive potassium channel in endocrine cells of the human ovary: role in membrane potential generation and steroidogenesis.
Kunz L, Richter JS, Mayerhofer A.
J Clin Endocrinol Metab 91, 1950-1955, 2006.

Transgenic mice expressing p450 aromatase as a model for male infertility associated with chronic inflammation in the testis.
Li X, Strauss L, Kaatrasalo A, Mayerhofer A, Huhtaniemi I, Santti R, Makela S, Poutanen M.
Endocrinology 147, 1271-1277, 2006.

FSH regulates acetycholine production by ovarian granulosa cells.
Mayerhofer A, Kunz L, Krieger A, Proskocil B, Spindel E, Amsterdam A, Dissen GA, Ojeda SR, Wessler I.
Reprod Biol Endocrinol 4, 37, 2006.

Non-neuronal acetylcholine and choline acetyltransferase in oviductal epithelial cells of cyclic and pregnant pigs.
Steffl M, Schweiger M, Wessler I, Kunz L, Mayerhofer A, Amselgruber WM.
Anat Embryol (Berl) 211, 685-690, 2006.

Prostate-specific antigen as allergen in human seminal plasma allergy.
Weidinger S, Mayerhofer A, Raemsch R, Ring J, Kohn FM.
J Allergy Clin Immunol 117, 213-215, 2006.

Evidence for a histaminergic system in the human testis.
Albrecht M, Frungieri MB, Gonzalez-Calvar S, Meineke V, Kohn FM, Mayerhofer A.
Fertil Steril 83, 1060-1063, 2005.

Divergent effects of the major mast cell products histamine, tryptase and TNF-alpha on human fibroblast behaviour.
Albrecht M, Frungieri MB, Kunz L, Ramsch R, Meineke V, Kohn FM, Mayerhofer A.
Cell Mol Life Sci 62, 2867-2876, 2005.

Insights into GABA receptor signalling in TM3 Leydig cells.
Doepner RF, Geigerseder C, Frungieri MB, Gonzalez-Calvar SI, Calandra RS, Raemsch R, Fohr K, Kunz L, Mayerhofer A.
Neuroendocrinology 81, 381-390, 2005.

Receptors and sites of synthesis and storage of gamma-aminobutyric acid in human pituitary glands and in growth hormone adenomas.
End K, Gamel-Didelon K, Jung H, Tolnay M, Ludecke D, Gratzl M, Mayerhofer A.
Am J Clin Pathol 124, 550-558, 2005.

The action of the mast cell product tryptase on cyclooxygenase-2 (COX2) and subsequent fibroblast proliferation involves activation of the extracellular signal-regulated kinase isoforms 1 and 2 (erk1/2).
Frungieri MB, Albrecht M, Raemsch R, Mayerhofer A.
Cell Signal 17, 525-533, 2005.

Direct effect of melatonin on Syrian hamster testes: melatonin subtype 1a receptors, inhibition of androgen production, and interaction with the local corticotropin-releasing hormone system.
Frungieri MB, Mayerhofer A, Zitta K, Pignataro OP, Calandra RS, Gonzalez-Calvar SI.
Endocrinology 146, 1541-1552, 2005.

A non-neuronal cholinergic system of the ovarian follicle.
Mayerhofer A, Kunz L.
Ann Anat 187, 521-528, 2005.

Tryptase inhibits motility of human spermatozoa mainly by activation of the mitogen-activated protein kinase pathway.
Weidinger S, Mayerhofer A, Kunz L, Albrecht M, Sbornik M, Wunn E, Hollweck R, Ring J, Kohn FM.
Hum Reprod 20, 456-461, 2005.

Two types of calcium channels in human ovarian endocrine cells: involvement in steroidogenesis.
Agoston A, Kunz L, Krieger A, Mayerhofer A.
J Clin Endocrinol Metab 89, 4503-4512, 2004.

Stimulation of TM3 Leydig cell proliferation via GABA(A) receptors: a new role for testicular GABA.
Geigerseder C, Doepner RF, Thalhammer A, Krieger A, Mayerhofer A.
Reprod Biol Endocrinol 2, 13, 2004.

Ovarian function and morphology after deletion of the DARPP-32 gene in mice.
Mayerhofer A, Fritz S, Mani S, Rajendra Kumar T, Thalhammer A, Ingrassia P, Fienberg AA, Greengard P.
Exp Clin Endocrinol Diabetes 112, 451-457, 2004.

Development and evaluation of a skin organ model for the analysis of radiation effects.
Meineke V, Muller K, Ridi R, Cordes N, Kohn FM, Mayerhofer A, Ring J, van Beuningen D.
Strahlenther Onkol 180, 102-108, 2004.

Molecular and physiological evidence for functional gamma-aminobutyric acid (GABA)-C receptors in growth hormone-secreting cells.
Gamel-Didelon K, Kunz L, Fohr KJ, Gratzl M, Mayerhofer A.
J Biol Chem 278, 20192-20195, 2003.

Evidence for a GABAergic system in rodent and human testis: local GABA production and GABA receptors.
Geigerseder C, Doepner R, Thalhammer A, Frungieri MB, Gamel-Didelon K, Calandra RS, Kohn FM, Mayerhofer A.
Neuroendocrinology 77, 314-323, 2003.

The expression and biological role of the non-neuronal cholinergic system in the ovary.
Mayerhofer A, Dimitrijevic N, Kunz L.
Life Sci 72, 2039-2045, 2003.

Modulation of X-ray-induced apoptosis in human keratinocytes (HaCaT) by 1,25-dihydroxyvitamin D3.
Meineke V, Pfaffendorf C, Schinn M, Tilgen W, Mayerhofer A, Dimitrijevic N, van Beuningen D, Reichrath J.
Recent Results Cancer Res 164, 427-432, 2003.

TNF-alpha induces apoptosis of parietal cells.
Neu B, Puschmann AJ, Mayerhofer A, Hutzler P, Grossmann J, Lippl F, Schepp W, Prinz C.
Biochem Pharmacol 65, 1755-1760, 2003.

Mast cell-sperm interaction: evidence for tryptase and proteinase-activated receptors in the regulation of sperm motility.
Weidinger S, Mayerhofer A, Frungieri MB, Meineke V, Ring J, Kohn FM.
Hum Reprod 18, 2519-2524, 2003.

Muscarinic receptors in human luteinized granulosa cells: activation blocks gap junctions and induces the transcription factor early growth response factor-1.
Fritz S, Kunz L, Dimitrijevic N, Grunert R, Heiss C, Mayerhofer A.
J Clin Endocrinol Metab 87, 1362-1367, 2002.

Number, distribution pattern, and identification of macrophages in the testes of infertile men.
Frungieri MB, Calandra RS, Lustig L, Meineke V, Kohn FM, Vogt HJ, Mayerhofer A.
Fertil Steril 78, 298-306, 2002.

Proliferative action of mast-cell tryptase is mediated by PAR2, COX2, prostaglandins, and PPARgamma : Possible relevance to human fibrotic disorders.
Frungieri MB, Weidinger S, Meineke V, Kohn FM, Mayerhofer A.
Proc Natl Acad Sci U S A 99, 15072-15077, 2002.

An autocrine role for pituitary GABA: activation of GABA-B receptors and regulation of growth hormone levels.
Gamel-Didelon K, Corsi C, Pepeu G, Jung H, Gratzl M, Mayerhofer A.
Neuroendocrinology 76, 170-177, 2002.

Ca2+-activated, large conductance K+ channel in the ovary: identification, characterization, and functional involvement in steroidogenesis.
Kunz L, Thalhammer A, Berg FD, Berg U, Duffy DM, Stouffer RL, Dissen GA, Ojeda SR, Mayerhofer A.
J Clin Endocrinol Metab 87, 5566-5574, 2002.

Changes in sympathetic nerve activity of the mammalian ovary during a normal estrous cycle and in polycystic ovary syndrome: Studies on norepinephrine release.
Lara HE, Dorfman M, Venegas M, Luza SM, Luna SL, Mayerhofer A, Guimaraes MA, Rosa ESAA, Ramirez VD.
Microsc Res Tech 59, 495-502, 2002.

Ovarian acetylcholine and muscarinic receptors: hints of a novel intrinsic ovarian regulatory system.
Mayerhofer A, Fritz S.
Microsc Res Tech 59, 503-508, 2002.

Protein kinase inhibitors modulate time-dependent effects of UV and ionizing irradiation on ICAM-1 expression on human hepatoma cells.
Meineke V, Moede T, Gilbertz KP, Mayerhofer A, Ring J, Kohn FM, Van Beuningen D.
Int J Radiat Biol 78, 577-583, 2002.

Helicobacter pylori induces apoptosis of rat gastric parietal cells.
Neu B, Randlkofer P, Neuhofer M, Voland P, Mayerhofer A, Gerhard M, Schepp W, Prinz C.
Am J Physiol Gastrointest Liver Physiol 283, G309-318, 2002.

Development of an experimental ovarian tumor: immunocytochemical analysis.
Sorianello E, Fritz S, Beyer C, Hales DB, Mayerhofer A, Libertun C, Lux-Lantos V.
Eur J Endocrinol 147, 387-395, 2002.

StAR protein is increased by muscarinic receptor activation in human luteinized granulosa cells.
Fritz S, Grunert R, Stocco DM, Hales DB, Mayerhofer A.
Mol Cell Endocrinol 171, 49-51, 2001.

Expression of muscarinic receptor types in the primate ovary and evidence for nonneuronal acetylcholine synthesis.
Fritz S, Wessler I, Breitling R, Rossmanith W, Ojeda SR, Dissen GA, Amsterdam A, Mayerhofer A.
J Clin Endocrinol Metab 86, 349-354, 2001.

Gamma-aminobutyric acid (GABA): a para- and/or autocrine hormone in the pituitary.
Mayerhofer A, Hohne-Zell B, Gamel-Didelon K, Jung H, Redecker P, Grube D, Urbanski HF, Gasnier B, Fritschy JM, Gratzl M.
FASEB J 15, 1089-1091, 2001.

Identification of an ovarian voltage-activated Na+-channel type: hints to involvement in luteolysis.
Bulling A, Berg FD, Berg U, Duffy DM, Stouffer RL, Ojeda SR, Gratzl M, Mayerhofer A.
Mol Endocrinol 14, 1064-1074, 2000.

Neuronal elements in the testis of the rhesus monkey: ontogeny, characterization and relationship to testicular cells.
Frungieri MB, Urbanski HF, Hohne-Zell B, Mayerhofer A.
Neuroendocrinology 71, 43-50, 2000.

Synaptosome-associated protein of 25 kilodaltons in oocytes and steroid-producing cells of rat and human ovary: molecular analysis and regulation by gonadotropins.
Grosse J, Bulling A, Brucker C, Berg U, Amsterdam A, Mayerhofer A, Gratzl M.
Biol Reprod 63, 643-650, 2000.

D1-Receptor, DARPP-32, and PP-1 in the primate corpus luteum and luteinized granulosa cells: evidence for phosphorylation of DARPP-32 by dopamine and human chorionic gonadotropin.
Mayerhofer A, Fritz S, Grunert R, Sanders SL, Duffy DM, Ojeda SR, Stouffer RL.
J Clin Endocrinol Metab 85, 4750-4757, 2000.

Human testicular mast cells contain tryptase: increased mast cell number and altered distribution in the testes of infertile men.
Meineke V, Frungieri MB, Jessberger B, Vogt H, Mayerhofer A.
Fertil Steril 74, 239-244, 2000.

Gap junction communication and connexin 43 gene expression in a rat granulosa cell line: regulation by follicle-stimulating hormone.
Sommersberg B, Bulling A, Salzer U, Frohlich U, Garfield RE, Amsterdam A, Mayerhofer A.
Biol Reprod 63, 1661-1668, 2000.

Identification of voltage-activated Na+ and K+ channels in human steroid-secreting ovarian cells.
Bulling A, Brucker C, Berg U, Gratzl M, Mayerhofer A.
Ann N Y Acad Sci 868, 77-79, 1999.

Functional and molecular characterization of a muscarinic receptor type and evidence for expression of choline-acetyltransferase and vesicular acetylcholine transporter in human granulosa-luteal cells.
Fritz S, Fohr KJ, Boddien S, Berg U, Brucker C, Mayerhofer A.
J Clin Endocrinol Metab 84, 1744-1750, 1999.

Sources and function of neuronal signalling molecules in the gonads.
Mayerhofer A, Frungieri MB, Bulling A, Fritz S.
Medicina (B Aires) 59, 542-545, 1999.

Evidence for catecholaminergic, neuronlike cells in the adult human testis: changes associated with testicular pathologies.
Mayerhofer A, Frungieri MB, Fritz S, Bulling A, Jessberger B, Vogt HJ.
J Androl 20, 341-347, 1999.

Functional dopamine-1 receptors and DARPP-32 are expressed in human ovary and granulosa luteal cells in vitro.
Mayerhofer A, Hemmings HC, Jr., Snyder GL, Greengard P, Boddien S, Berg U, Brucker C.
J Clin Endocrinol Metab 84, 257-264, 1999.

Oocytes are a source of catecholamines in the primate ovary: evidence for a cell-cell regulatory loop.
Mayerhofer A, Hemmings HC, Jr., Snyder GL, Greengard P, Boddien S, Berg U, Brucker C.
Proc Natl Acad Sci U S A 95, 10990-10995, 1998.

Birth of healthy children after intracytoplasmic sperm injection in two couples with male Kartagener's syndrome.
von Zumbusch A, Fiedler K, Mayerhofer A, Jessberger B, Ring J, Vogt HJ.
Fertil Steril 70, 643-646, 1998.

A role for neurotransmitters in early follicular development: induction of functional follicle-stimulating hormone receptors in newly formed follicles of the rat ovary.
Mayerhofer A, Dissen GA, Costa ME, Ojeda SR.
Endocrinology 138, 3320-3329, 1997.

Visualizing the expression of a human growth hormone (hGH) transgene in the liver: intrahepatic regional and intracellular differences of expression are associated with morphological alterations and hepatocellular proliferation.
Vergani G, Lahr G, Wang ZM, Bartke A, Mayerhofer A.
Tissue Cell 29, 611-616, 1997.

Participation of nerve growth factor in the regulation of ovarian function.
Dissen GA, Mayerhofer A, Ojeda SR.
Zygote 4, 309-312, 1996.

Chromogranin A immunoreactivity in epithelial cells of the thymus.
Ginda WJ, Gratzl M, Mayerhofer A, Warchol JB.
Folia Histochem Cytobiol 34, 91-93, 1996.

Testis of prepubertal rhesus monkeys receives a dual catecholaminergic input provided by the extrinsic innervation and an intragonadal source of catecholamines.
Ginda WJ, Gratzl M, Mayerhofer A, Warchol JB.
Biol Reprod 55, 509-518, 1996.

Involvement of nerve growth factor in the ovulatory cascade: trkA receptor activation inhibits gap junctional communication between thecal cells.
Mayerhofer A, Dissen GA, Parrott JA, Hill DF, Mayerhofer D, Garfield RE, Costa ME, Skinner MK, Ojeda SR.
Endocrinology 137, 5662-5670, 1996.

The neural cell adhesion molecule (NCAM) provides clues to the development of testicular Leydig cells.
Mayerhofer A, Lahr G, Seidl K, Eusterschulte B, Christoph A, Gratzl M.
J Androl 17, 223-230, 1996.